Research in the White Lab focuses on high resolution, quantitative characterization of intracellular proteome dynamics regulating normal and pathophysiological processes, with the ultimate goal of defining novel therapeutic targets and therapeutic combinations. To this end, we use mass spectrometry to profile the dynamics of protein phosphorylation and antigen presentation in model systems of human disease, especially cancer, and in primary human tissues.

Celebrating the lab's 20th anniversary at MIT!
Our mass spectrometry lab, where four high-resolution Orbitrap instruments allow us to quantify thousands of proteins in health and disease.
Analysis of tyrosine kinase signaling in triple-negative breast cancer (Kohale et al. Cancers 2022)
Protein and phosphoprotein levels in postmortem brain tissue of patients with and without Alzheimer's disease (Morshed et al. Nat Aging 2021)
A workflow for absolute quantitation of tumor-associated antigens (Stopfer et al. PNAS 2021)

The White lab is committed to the success of all trainees at all levels in an inclusive, culturally diverse, and intellectually interdisciplinary lab environment.  We are especially dedicated to the support of underrepresented groups in terms of race, gender, and sexual identity in all aspects of life, including as scientists and engineers in our lab, as collaborators in our research, and as leaders in our field. We actively welcome URM high school and undergraduate students to participate in summer or semesterly internships, and for URM prospective graduate students and post-docs to apply to our lab. Please reach out to us directly, or apply to programs like MSRP and EXROP (for non-MIT undergrads), BE, CSB, and HST (for prospective grad students). Research should be a fun and exciting adventure that is facilitated by collegial teamwork, mutual respect, and thoughtful consideration.