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Flower CT*, Liu C*, Chuang H-Y, Ye X, Cheng H, Heath JR**, Wei W**, White FM**. Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition. bioRxiv. 2024;581004


Recent research articles

Alkhatib H*, Conage-Pough J*, Chowdhury SR, Shian D, Zaid D, Rubinstein AM, Sonnenblick A, Peretz-Yablonsky T, Granit A, Carmon E, Kohale IN, Boughey JC, Goetz MP, Wang L, White FM**, Kravchenko-Balasha N**. Patient-specific signaling signatures predict optimal therapeutic combinations for triple negative breast cancer. Mol Cancer. 2024;23(1):17.

Rousseau E*, Raman R*, Tamir T*, Bu A, Srinivasan S, Lynch N, Langer R, White FM, Cima MJ. Actuated tissue engineered muscle grafts restore functional mobility after volumetric muscle loss. Biomaterials. 2023;302:122317.

Conage-Pough JE*, Stopka SA*, Oh JH, Mladek AC, Burgenske DM, Regan MS, Baquer G, Decker PA, Carlson BL, Bakken KK, Zhang J, Liu L, Sun C, Mu Z, Zhong W, Tran NL, Elmquist WF, Agar NYR, Sarkaria JN, White FM. WSD-0922, a novel brain-penetrant inhibitor of EGFR, promotes survival in glioblastoma mouse models. Neurooncol Adv. 2023;5(1):vdad066.

Gerritsen JS, Faraguna JS, Bonavia R, Furnari FB, White FM. Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network. Life Sci Alliance. 2023;6(8):e202201466.

Leddy O, White FM, Bryson BD. Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I. Elife. 2023;12:e84070.

Stopfer LE*, Rettko NJ*, Leddy O, Mesfin JM, Brown E, Winski S, Bryson B, Wells JA, White FM. MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas. Proc Natl Acad Sci USA. 2022;119(49):e2208900119.

Kohale IN, Yu J, Zhuang Y, Fan X, Reddy RJ, Sinnwell J, Kalari KR, Boughey JC, Carter JM, Goetz MP, Wang L, White FM. Identification of Src family kinases as potential therapeutic targets for chemotherapy-resistant triple negative breast cancer. Cancers. 2022;14(17):4220.

Fessenden TB*, Stopfer LE*, Chatterjee F*, Zulueta J, Mesfin J, Cordero Dumit T, Reijers I, Hoefsmit EP, Blank C, White F, Spranger S. Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins. J Immunother Cancer. 2022;10(7):e004159.

Lopez BGC*, Kohale IN*, Du Z*, Korsunsky I, Abdelmoula WM, Dai Y, Stopka SA, Gaglia G, Randall EC, Regan MS, Basu SS, Clark AR, Marin BM, Mladek AC, Burgenske DM, Agar JN, Supko JG, Grossman SA, Nabors LB, Raychaudhuri S, Ligon KL, Wen PY, Alexander B, Lee EQ, Santagata S**, Sarkaria J**, White FM**, Agar NYR**. Multimodal platform for assessing drug distribution and response in clinical trials. Neuro Oncol. 2022;24(1):64-77.

Stopfer LE, Gajadhar AS, Patel B, Gallien S, Frederick DT, Boland GM, Sullivan RJ, White FM. Absolute quantification of tumor antigens using embedded MHC-I isotopologue calibrants. Proc Natl Acad Sci USA. 2021;118(37):e2111173118.


Review articles, book chapters, & perspectives

Gerritsen J, Rizzo S, Thevenin D, White FM. System-level analysis of the effects of RPTPs on cellular signaling networksMethods Mol Biol. 2024;2743:153-63.

Herbst SA, White FM. Decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational modifications. Cell Rep Methods. 2023;3(5):100483.

Ahn R, Cui Y, White FM. Antigen discovery for the development of cancer immunotherapy. Semin Immunol. 2023;66:101733.

Stopfer LE, D'Souza AD, White FM. 1,2,3 MHC: a review of mass spectrometry-based immunopeptidomics methods for relative and absolute quantification of pMHCs. Immunooncol Technol. 2021;100042.

Gerritsen JS, White FM. Phosphoproteomics: a valuable tool for uncovering molecular signaling in cancer cells. Expert Rev Proteomics. 2021;18(8):661-74.

Leddy OK, White FM, Bryson BD. Leveraging immunopeptidomics to study and combat infectious disease. mSystems. 2021;6(4):e0031021.

Johnson H, White FM. Quantitative analysis of tyrosine kinase signaling across differentially embedded human glioblastoma tumors. Methods Mol Biol. 2018;1711:149-64.

Reddy RJ, Curran TG, Zhang Y, White FM. Measurement of phosphorylated peptides with absolute quantification. Methods Mol Biol. 2016;1410:281-92.

Rothenberg DA, Gordon EA, White FM, Lourido S. Identification of direct kinase substrates using analogue-sensitives alleles. Methods Mol Biol. 2016;1355:71-84.

Haley J, White FM. Adaptive protein and phosphoprotein networks which promote therapeutic sensitivity or acquired resistance. Biochem Soc Trans. 2014;42(4):758-64.


Most cited

Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Mol Cell Proteomics. 2005;4(9):1240-50.

Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM. Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proc Natl Acad Sci USA. 2007;104(14):5860-5.

Huang PH, Mukasa A, Bonavia R, Flynn RA, Brewer ZE, Cavanee WK, Furnari FB, White FM. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. Proc Natl Acad Sci USA. 2007;104(31):12867-72.

Huang PH, Xu AM, White FM. Oncogenic EGFR signaling networks in glioma. Sci Signal. 2009;2(87):re6.

Wolf-Yadlin A, Kumar N, Zhang Y, Hautaniemi S, Zaman M, Kim HD, Grantcharova Y, Lauffenburger DA, White FM. Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Mol Syst Biol. 2006;2:54.

Schmelzle K, Kane S, Gridley S, Lienhard GE, White FM. Temporal dynamics of tyrosine phosphorylation in insulin signalingDiabetes. 2006;55(8):2171-9.

Nita-Lazar A, Saito-Benz H, White FM. Quantitative phosphoproteomics by mass spectrometry: past, present, and future. Proteomics. 2008;8(21):4433-43.

Moser K, White FM. Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS. J Proteome Res. 2006;5(1):98-104.

Schmelzle K, White FM. Phosphoproteomic approaches to elucidate cellular signaling networks. Curr Opin Biotechnol. 2006;17(4):406-14.

Carlson SM, Chouinard CR, Labadorf A, Lam CJ, Schmelzle K, Fraenkel E, White FM. Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3. Sci Signal. 2011;4(196):rs11.