Publications

Toure MA, Motoyama K, Xiang Y, Urgiles J, Kabinger F, Koglin A, Iyer RS, Gagnon K, Kumar A, Ojeda S, Harrison DA, G Rees MG, Roth JA, Ott CJ, Schiavoni R, Whittaker CA, Levine SS, White FM, Calo E, Richters A, Koehler AN. Targeted degradation of CDK9 potently disrupts the MYC-regulated network. Cell Chem. Biol. 2025 Mar 25:S2451-9456(25)00067-4.

Flower CT, Liu C, Chuang H, Ye X, Cheng H, Heath JR, Wei W, White FM. Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition. Cell Syst. 2025 Mar 17:101239.

Latchford LP, Perez LS, Conage-Pough JE, Turk R, Cusimano MA, Vargas VI, Arora S, Shienvold SR, Kulp RR, Belverio HM, White FM, Thévenin AF. Differential substrate specificity of ERK, JNK, and p38 MAP kinases toward connexin 43. J Biol Chem. 2025 Jan 10;301(3):108178.

Hillis AL, Tamir T, Perry GE, Asara JM, Johnson JL, Yaron TM, Cantley LC, White FM, Toker A. Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome. Proc Natl Acad Sci USA. 2024 Nov 19;121(47):e2413837121.

Roerden M, Castro AB, Cui Y, Harake N, Kim B, Dye J, Maiorino L, White FM, Irvine DJ, Litchfield K, Spranger S. Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression. J Immunother Cancer. 2024 Nov 9;12(11):e010249.

Leddy O, Cui Y, Ahn R, Stopfer L, Choe E, Kim DH, Roerden M, Spranger S, Bryson BD, White FM. Validation and quantification of peptide antigens presented on MHCs using SureQuant. Nat Protoc (2024).

Alkhatib H*, Conage-Pough J*, Chowdhury SR, Shian D, Zaid D, Rubinstein AM, Sonnenblick A, Peretz-Yablonsky T, Granit A, Carmon E, Kohale IN, Boughey JC, Goetz MP, Wang L, White FM**, Kravchenko-Balasha N**. Patient-specific signaling signatures predict optimal therapeutic combinations for triple negative breast cancer. Mol Cancer. 2024;23(1):17.

Conage-Pough JE*, Stopka SA*, Oh JH, Mladek AC, Burgenske DM, Regan MS, Baquer G, Decker PA, Carlson BL, Bakken KK, Zhang J, Liu L, Sun C, Mu Z, Zhong W, Tran NL, Elmquist WF, Agar NYR, Sarkaria JN, White FM. WSD-0922, a novel brain-penetrant inhibitor of EGFR, promotes survival in glioblastoma mouse models. Neurooncol Adv. 2023;5(1):vdad066.

Gerritsen JS, Faraguna JS, Bonavia R, Furnari FB, White FM. Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network. Life Sci Alliance. 2023;6(8):e202201466.

Leddy O, White FM, Bryson BD. Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I. Elife. 2023;12:e84070.

Stopfer LE*, Rettko NJ*, Leddy O, Mesfin JM, Brown E, Winski S, Bryson B, Wells JA, White FM. MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas. Proc Natl Acad Sci USA. 2022;119(49):e2208900119.

Kohale IN, Yu J, Zhuang Y, Fan X, Reddy RJ, Sinnwell J, Kalari KR, Boughey JC, Carter JM, Goetz MP, Wang L, White FM. Identification of Src family kinases as potential therapeutic targets for chemotherapy-resistant triple negative breast cancer. Cancers. 2022;14(17):4220.

Fessenden TB*, Stopfer LE*, Chatterjee F*, Zulueta J, Mesfin J, Cordero Dumit T, Reijers I, Hoefsmit EP, Blank C, White F, Spranger S. Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins. J Immunother Cancer. 2022;10(7):e004159.

Lopez BGC*, Kohale IN*, Du Z*, Korsunsky I, Abdelmoula WM, Dai Y, Stopka SA, Gaglia G, Randall EC, Regan MS, Basu SS, Clark AR, Marin BM, Mladek AC, Burgenske DM, Agar JN, Supko JG, Grossman SA, Nabors LB, Raychaudhuri S, Ligon KL, Wen PY, Alexander B, Lee EQ, Santagata S**, Sarkaria J**, White FM**, Agar NYR**. Multimodal platform for assessing drug distribution and response in clinical trials. Neuro Oncol. 2022;24(1):64-77.

Stopfer LE, Gajadhar AS, Patel B, Gallien S, Frederick DT, Boland GM, Sullivan RJ, White FM. Absolute quantification of tumor antigens using embedded MHC-I isotopologue calibrants. Proc Natl Acad Sci USA. 2021;118(37):e2111173118.

Leddy O, Ogongo P, Huffaker J, Gan M, Milligan R, Mahmud S, Yuki Y, Bobosha K, Wassie L, Carrington M, Liu Q, Ernst JD, White FM, Bryson BD. Immunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design. bioRxiv. 2024;616386.

Leddy O, Yuki Y, Carrington M, Bryson BD, White FM. PathMHC: a workflow to selectively target pathogen-derived MHC peptides in discovery immunopeptidomics experiments for vaccine target identification.bioRxiv. 2024;612454.

Tamir TY, Chaudhary S, Li AX, Trojan SE, Flower CT, Vo P, Cui Y, Davis JC, Mukkamala RS, Venditti FN, Hillis AL, Toker A, Vander Heiden MG, Spinelli JB, Kennedy NJ, Davis RJ, White FM. Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity. bioRxiv. 2024;609894.

Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Mol Cell Proteomics. 2005;4(9):1240-50.

Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM. Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proc Natl Acad Sci USA. 2007;104(14):5860-5.

Huang PH, Mukasa A, Bonavia R, Flynn RA, Brewer ZE, Cavanee WK, Furnari FB, White FM. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. Proc Natl Acad Sci USA. 2007;104(31):12867-72.

Huang PH, Xu AM, White FM. Oncogenic EGFR signaling networks in glioma. Sci Signal. 2009;2(87):re6.

Wolf-Yadlin A, Kumar N, Zhang Y, Hautaniemi S, Zaman M, Kim HD, Grantcharova Y, Lauffenburger DA, White FM. Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Mol Syst Biol. 2006;2:54.

Schmelzle K, Kane S, Gridley S, Lienhard GE, White FM. Temporal dynamics of tyrosine phosphorylation in insulin signaling. Diabetes. 2006;55(8):2171-9.

Nita-Lazar A, Saito-Benz H, White FM. Quantitative phosphoproteomics by mass spectrometry: past, present, and future. Proteomics. 2008;8(21):4433-43.

Moser K, White FM. Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS. J Proteome Res. 2006;5(1):98-104.

Schmelzle K, White FM. Phosphoproteomic approaches to elucidate cellular signaling networks. Curr Opin Biotechnol. 2006;17(4):406-14.

Carlson SM, Chouinard CR, Labadorf A, Lam CJ, Schmelzle K, Fraenkel E, White FM. Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3. Sci Signal. 2011;4(196):rs11.

Coon JJ, Marto JA, Syka JEP, White FM. The Hunt lab weighs in on mass spectrometry-based analysis of protein post-translational modifications. Mol Cell Proteomics. 2025 Mar 11:100943.

Gerritsen J, Rizzo S, Thevenin D, White FM. System-level analysis of the effects of RPTPs on cellular signaling networks. Methods Mol Biol. 2024;2743:153-63.

Herbst SA, White FM. Decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational modifications. Cell Rep Methods. 2023;3(5):100483.

Ahn R, Cui Y, White FM. Antigen discovery for the development of cancer immunotherapy. Semin Immunol. 2023;66:101733.

Stopfer LE, D’Souza AD, White FM. 1,2,3 MHC: a review of mass spectrometry-based immunopeptidomics methods for relative and absolute quantification of pMHCs. Immunooncol Technol. 2021;100042.

Gerritsen JS, White FM. Phosphoproteomics: a valuable tool for uncovering molecular signaling in cancer cells. Expert Rev Proteomics. 2021;18(8):661-74.

Leddy OK, White FM, Bryson BD. Leveraging immunopeptidomics to study and combat infectious disease. mSystems. 2021;6(4):e0031021.

Johnson H, White FM. Quantitative analysis of tyrosine kinase signaling across differentially embedded human glioblastoma tumors. Methods Mol Biol. 2018;1711:149-64.

Reddy RJ, Curran TG, Zhang Y, White FM. Measurement of phosphorylated peptides with absolute quantification. Methods Mol Biol. 2016;1410:281-92.

Rothenberg DA, Gordon EA, White FM, Lourido S. Identification of direct kinase substrates using analogue-sensitives alleles. Methods Mol Biol. 2016;1355:71-84.

Haley J, White FM. Adaptive protein and phosphoprotein networks which promote therapeutic sensitivity or acquired resistance. Biochem Soc Trans. 2014;42(4):758-64.