Publications

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2016

Lescarbeau RS, Lei L, Bakken KK, Sims PA, Sarkaria JN, Canoll P, White FM. Quantitative Phosphoproteomics Reveals Wee1 Kinase as a Therapeutic Target in a Model of Proneural Glioblastoma. Mol Cancer Ther. 2016 Jun;15(6):1332-43. doi: 10.1158/1535-7163.MCT-15-0692-T. Epub 2016 May 17. PubMed PMID: 27196784; PubMed Central PMCID: PMC4893926.

Reddy RJ, Gajadhar AS, Swenson EJ, Rothenberg DA, Curran TG, White FM. Early signaling dynamics of the epidermal growth factor receptor. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3114-9.doi: 10.1073/pnas.1521288113. Epub 2016 Feb 29. PubMed PMID: 26929352; PubMed Central PMCID: PMC4801278.

2015

Levin VA, Tonge PJ, Gallo JM, Birtwistle MR, Dar AC, Iavarone A, Paddison PJ, Heffron TP, Elmquist WF, Lachowicz JE, Johnson TW, White FM, Sul J, Smith QR, Shen W, Sarkaria JN, Samala R, Wen PY, Berry DA, Petter RC. CNS Anticancer Drug Discovery and Development Conference White Paper. Neuro Oncol. 2015 Nov;17 Suppl 6:vi1-26. doi: 10.1093/neuonc/nov169. PubMed PMID: 26403167; PubMed Central PMCID: PMC4581696.

Hughes SK, Oudin MJ, Tadros J, Neil J, Del Rosario A, Joughin BA, Ritsma L, Wyckoff J, Vasile E, Eddy R, Philippar U, Lussiez A, Condeelis JS, van Rheenen J, White F, Lauffenburger DA, Gertler FB. PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Mol Biol Cell. 2015 Nov 1;26(21):3867-78. doi: 10.1091/mbc.E15-06-0442. Epub 2015 Sep 2. PubMed PMID: 26337385; PubMed Central PMCID: PMC4626070.

McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD. Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29. PubMed PMID: 26025730; PubMed Central PMCID: PMC4526337.

Gajadhar AS, Johnson H, Slebos RJ, Shaddox K, Wiles K, Washington MK, Herline AJ, Levine DA, Liebler DC, White FM; Clinical Proteomic Tumor Analysis Consortium. Phosphotyrosine signaling analysis in human tumors is confounded by systemic ischemia-driven artifacts and intra-specimen heterogeneity. Cancer Res. 2015 Apr 1;75(7):1495-503. doi: 10.1158/0008-5472.CAN-14-2309. Epub 2015 Feb 10. PubMed PMID: 25670172; PubMed Central PMCID: PMC4383696.

Curran TG, Zhang Y, Ma DJ, Sarkaria JN, White FM. MARQUIS: a multiplex method for absolute quantification of peptides and posttranslational modifications. Nat Commun. 2015 Jan 12;6:5924.doi: 10.1038/ncomms6924. PubMed PMID: 25581283; PubMed Central PMCID: PMC4293043.

Bryson BD, White FM. Quantitative Profiling of Lysine Acetylation Reveals Dynamic Crosstalk between Receptor Tyrosine Kinases and Lysine Acetylation. PLoS One. 2015 May 15;10(5):e0126242.doi: 10.1371/journal.pone.0126242. eCollection 2015. PubMed PMID: 25978619; PubMed Central PMCID: PMC4433260`

2014

Johnson H, White FM. Quantitative analysis of signaling networks across differentially embedded tumors highlights interpatient heterogeneity in human glioblastoma. J Proteome Res. 2014 Nov 7;13(11):4581-93.PubMed PMID: 24927040; PubMed Central PMCID:PMC4227552.

Bell EL, Nagamori I, Williams EO, Del Rosario AM, Bryson BD, et al. SirT1 is required in the male germ cell for differentiation and fecundity in mice. Development. 2014 Sep;141(18):3495-504. PubMed PMID: 25142464; PubMed Central PMCID:PMC4197722.

Haley J, White FM.Adaptive protein and phosphoprotein networks which promote therapeutic sensitivity or acquired resistance.Biochem Soc Trans. 2014 Aug;42(4):758-64.PubMed PMID: 25109954.

Gajadhar AS, White FM.System level dynamics of posttranslational modifications. Curr Opin Biotechnol. 2014 Aug;28:83-7.PubMed PMID: 24441143; NIHMSID: NIHMS558903; PubMed Central PMCID:PMC4097989.

Mertins P, Yang F, Liu T, Mani DR, Petyuk VA, et al. Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.PubMed PMID: 24719451; PubMed Central PMCID:PMC4083109.

Arneja A, Johnson H, Gabrovsek L, Lauffenburger DA, White FM. Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration. J Immunol. 2014 Jan 1;192(1):123-35. PubMed PMID: 24298013; NIHMSID: NIHMS539170; PubMed Central PMCID:PMC3950894.

 

2013

Hang TC, Tedford NC, Reddy RJ, Rimchala T, Wells A, et al. Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context. Mol Cell Proteomics. 2013 Dec;12(12):3704-18.PubMed PMID: 24023389; PubMed Central PMCID:PMC3861718.

Berchowitz LE, Gajadhar AS, van Werven FJ, De Rosa AA, Samoylova ML, et al.A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern. Genes Dev. 2013 Oct 1;27(19):2147-63. PubMed PMID: 24115771; PubMed Central PMCID:PMC3850098.

Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, et al. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb). 2013 Jul 24;5(7):940-63.PubMed PMID: 23685806; NIHMSID: NIHMS482406; PubMed Central PMCID:PMC3759823.

Curran TG, Bryson BD, Reigelhaupt M, Johnson H, White FM. Computer aided manual validation of mass spectrometry-based proteomic data. Methods. 2013 Jun 15;61(3):219-26.PubMed PMID: 23500044; NIHMSID: NIHMS471062; PubMed Central PMCID:PMC3700613.

Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 2013 Jun 13;498(7453):246-50. PubMed PMID: 23728299; NIHMSID: NIHMS463907; PubMed Central PMCID:PMC3683358.

Johnson H, Lescarbeau RS, Gutierrez JA, White FM. Phosphotyrosine profiling of NSCLC cells in response to EGF and HGF reveals network specific mediators of invasion. J Proteome Res. 2013 Apr 5;12(4):1856-67.PubMed PMID: 23438512; NIHMSID: NIHMS556553; PubMed Central PMCID:PMC3950895.

 

2012

Winter GE, Rix U, Carlson SM, Gleixner KV, Grebien F, et al. Systems-pharmacology dissection of a drug synergy in imatinibresistant CML. Nat Chem Biol. 2012 Nov;8(11):905-12.PubMed PMID: 23023260; NIHMSID: NIHMS579706; PubMed Central PMCID:PMC4038039.

Naegle KM, White FM, Lauffenburger DA, Yaffe MB. Robust coregulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions. Mol Biosyst. 2012 Oct;8(10):2771-82. PubMed PMID: 22851037; NIHMSID: NIHMS402706; PubMed Central PMCID:PMC3501258.

Johnson H, White FM. Toward quantitative phosphotyrosine profiling in vivo.Semin Cell Dev Biol. 2012 Oct;23(8):854-62. PubMed PMID: 22677333; NIHMSID: NIHMS389550; PubMed Central PMCID:PMC3496061.

Carlson SM, White FM. Labeling and identification of direct kinase substrates.Sci Signal. 2012 Jun 5;5(227):pl3.PubMed PMID: 22669844; NIHMSID: NIHMS477980; PubMed Central PMCID: PMC3690949.

 

2011

Carlson SM, Chouinard CR, Labadorf A, Lam CJ, Schmelzle K, et al. Large-scale discovery of ERK2 substrates identifies ERKmediated transcriptional regulation by ETV3.Sci Signal. 2011 Oct 25;4(196):rs11.PubMed PMID: 22028470; NIHMSID: NIHMS477806; PubMed Central PMCID:PMC3779841.

Hagen DR, Apgar JF, Witmer DK, White FM, Tidor B. Reply to Comment on "Sloppy models, parameter uncertainty, and the role of experimental design". Mol Biosyst. 2011 Aug 1;7(8):2523- 2524.PubMed PMID: 23148131; NIHMSID: NIHMS414670; PubMed Central PMCID:PMC3495004.

 

2010

Pines G, Huang PH, Zwang Y, White FM, Yarden Y.EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism. Oncogene. 2010 Oct 28;29(43):5850- 60.PubMed PMID: 20676128; NIHMSID: NIHMS452710; PubMed Central PMCID:PMC3634975.

Apgar JF, Witmer DK, White FM, Tidor B.Sloppy models, parameter uncertainty, and the role of experimental design. Mol Biosyst. 2010 Oct;6(10):1890-900.PubMed PMID: 20556289; NIHMSID: NIHMS414667; PubMed Central PMCID:PMC3505121.

Lahesmaa-Korpinen AM, Carlson SM, White FM, Hautaniemi S. Integrated data management and validation platform for phosphorylated tandem mass spectrometry data.Proteomics. 2010 Oct;10(19):3515-24.PubMed PMID: 20827731; NIHMSID: NIHMS259961; PubMed Central PMCID:PMC3017393.

Huang PH, Miraldi ER, Xu AM, Kundukulam VA, Del Rosario AM, et al.Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth. Mol Biosyst. 2010 Jul;6(7):1227-37. PubMed PMID: 20461251; NIHMSID: NIHMS358410; PubMed Central PMCID:PMC3291333.

Iwai LK, Benoist C, Mathis D, White FM. Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice. J Proteome Res. 2010 Jun 4;9(6):3135-45.PubMed PMID: 20438120; NIHMSID: NIHMS207342; PubMed Central PMCID:PMC3603002.

Del Rosario AM, White FM. Quantifying oncogenic phosphotyrosine signaling networks through systems biology. Curr Opin Genet Dev. 2010 Feb;20(1):23-30.PubMed PMID: 20074929; NIHMSID: NIHMS483005; PubMed Central PMCID: PMC3694410.

 

2009 and earlier

Stevens AL, Wishnok JS, White FM, Grodzinsky AJ, Tannenbaum SR. Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair. Mol Cell Proteomics. 2009 Jul;8(7):1475-89.PubMed PMID: 19196708; PubMed Central PMCID:PMC2709180.

Joughin BA, Naegle KM, Huang PH, Yaffe MB, Lauffenburger DA, et al.An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells. Mol Biosyst. 2009 Jan;5(1):59-67.PubMed PMID: 19081932; NIHMSID: NIHMS105339; PubMed Central PMCID:PMC2701618.

Nita-Lazar A, Saito-Benz H, White FM. Quantitative phosphoproteomics by mass spectrometry: past, present, and future.Proteomics. 2008 Nov;8(21):4433-43.PubMed PMID: 18846511; NIHMSID: NIHMS105336; PubMed Central PMCID: PMC2701620.

Huang PH, White FM.Phosphoproteomics: unraveling the signaling web. Mol Cell. 2008 Sep 26;31(6):777-81.PubMed PMID: 18922462; NIHMSID: NIHMS105341; PubMed Central PMCID: PMC2754874.

White FM. Quantitative phosphoproteomic analysis of signaling network dynamics. Curr Opin Biotechnol. 2008 Aug;19(4):404-9. PubMed PMID: 18619541; NIHMSID: NIHMS69039; PubMed Central PMCID:PMC2567239.

Schmelzle K, Kane S, Gridley S, Lienhard GE, White FM. Temporal dynamics of tyrosine phosphorylation in insulin signaling. Diabetes. 2006 Aug;55(8):2171-9.PubMed PMID: 16873679.

Kim JE, White FM. Quantitative analysis of phosphotyrosine signaling networks triggered by CD3 and CD28 costimulation in Jurkat cells. J Immunol. 2006 Mar 1;176(5):2833-43.PubMed PMID: 16493040.

Moser K, White FM.Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS. J Proteome Res. 2006 Jan;5(1):98-104.PubMed PMID: 16396499.

Kim JE, Tannenbaum SR, White FM. Global phosphoproteome of HT-29 human colon adenocarcinoma cells. J Proteome Res. 2005 Jul-Aug;4(4):1339-46.PubMed PMID: 16083285.

Chen WG, White FM.Proteomic analysis of cellular signaling. Expert Rev Proteomics. 2004 Oct;1(3):343-54.PubMed PMID: 15966830.

 

White Lab publications on PubMed